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KMID : 0383820100690060465
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Tuberculosis and Respiratory Diseases
2010 Volume.69 No. 6 p.465 ~ p.468
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Erlotinib-Related Spontaneous Pneumothorax in Patient with Primary Lung Cancer
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Nam Hae-Seong
Lee Hyeon-Jeong
Kim Min-Su
Park Sung-Wook
Jeon Sang-Hoon
Cho Jae-Hwa
Kwak Seung-Min
Lee Hong-Lyeol
Ryu Jeong-Seon
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Abstract
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Spontaneous pneumothorax (SPTx) associated with primary lung cancer is quite rare, but has been reported as the initial presentation or a complication of disease progression. Moreover, chemotherapy-related SPTx in primary lung cancer occurs at a very low frequency, accounting for less than 0.05% of all cases. Here, we report the first case of erlotinib-related SPTx in a patient with advanced lung adenocarcinoma in Korea. After 3 cycles of cisplatin-based chemotherapy as first-line therapy, erlotinib was administered as second-line treatment. Asymptomatic SPTx accompanied by a significant decrease in tumor size was observed in the left lung 7 weeks later. The patient received continuous administration of erlotinib, without additional treatment. This case showed that SPTx can occur in patients with primary lung cancer receiving erlotinib, and asymptomatic chemotherapy-related SPTx in primary lung cancer may not require therapeutic intervention.
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KEYWORD
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Pneumothorax, Lung neoplasm, erlotinib
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